一个令人兴奋的 iPSC 疾病模型：长 QT 综合征 2 型和心脏细胞在培养皿中。

An electrifying iPSC disease model: long QT syndrome type 2 and heart cells in a dish.

机构信息

Department of Medicine, University of Wisconsin School of Medicine and Public Health, Clinical Science Center, 600 Highland Avenue, Madison, WI 53792-3248 USA.

出版信息

Cell Stem Cell. 2011 Feb 4;8(2):130-1. doi: 10.1016/j.stem.2011.01.010.

DOI:10.1016/j.stem.2011.01.010

PMID:21295269

Abstract

In a recent Nature paper, Itzhaki et al. (2011) generate induced pluripotent stem cells (iPSCs) from patients with a potentially fatal inherited arrhythmia, long QT syndrome type 2. Cardiomyocytes differentiated from the patient-derived iPSCs exhibit the hallmark cardiac electrical signatures of the disease, which can be reversed by pharmacological intervention.

摘要

在最近的《自然》杂志上，Itzhaki 等人（2011 年）从患有潜在致命遗传性心律失常、长 QT 综合征 2 型的患者中生成诱导多能干细胞（iPSCs）。从患者来源的 iPSCs 分化而来的心肌细胞表现出该疾病的标志性心脏电特征，可通过药物干预逆转。