Institute of Neurological Sciences, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, UK.
Muscle Nerve. 2011 Mar;43(3):329-34. doi: 10.1002/mus.21880. Epub 2011 Feb 8.
The Oculobulbar Facial Respiratory (OBFR) score is a tool that objectively measures bulbar function in myasthenia gravis (MG). In this study, we analyzed the relation between the OBFR and the MG Activities of Daily Living (MG-ADL) score, and also with the more recently described MG Composite and 15-item MG Quality-of-Life (MG-QOL15) scales. We recruited 42 patients from two centers and assessed them on two occasions, approximately 6 months apart, using the OBFR, MG Composite, MG-ADL, and MG-QOL15 scales. The 'modified' OBFR score was derived from the original OBFR score. The OBFR score correlated significantly with the MG Composite, MG-ADL, and MG-QOL15 scores for both assessments, and with the sum of the bulbar items for all three scores. It also correlated strongly with the individual bulbar-related items of all three scores. The 'modified' OBFR score also correlated significantly with all the aforementioned scores. This study confirmed construct validity of the OBFR and 'modified' OBFR scores.
眼-面-呼吸(OBFR)评分是一种客观测量重症肌无力(MG)球部功能的工具。本研究分析了 OBFR 与 MG 日常生活活动(MG-ADL)评分之间的关系,以及与最近描述的 MG 综合评分和 15 项 MG 生活质量(MG-QOL15)评分之间的关系。我们从两个中心招募了 42 名患者,并在大约 6 个月的时间里两次使用 OBFR、MG 综合评分、MG-ADL 和 MG-QOL15 评分对他们进行评估。“改良”OBFR 评分是从原始 OBFR 评分中得出的。在两次评估中,OBFR 评分与 MG 综合评分、MG-ADL 评分和 MG-QOL15 评分均显著相关,与所有三个评分的球部项目总和也显著相关。它还与所有三个评分的各个与球部相关的项目密切相关。“改良”OBFR 评分也与上述所有评分显著相关。本研究证实了 OBFR 和“改良”OBFR 评分的结构效度。