老年小鼠流感病毒感染中的 CD8 T 细胞反应。
CD8 T cell responses to influenza virus infection in aged mice.
机构信息
Department of Biology, Drexel University, Philadelphia, PA 19104, USA.
出版信息
Ageing Res Rev. 2011 Sep;10(4):422-7. doi: 10.1016/j.arr.2011.02.001. Epub 2011 Feb 15.
Influenza is one of the most common infectious diseases afflicting humans, particularly the elderly. The murine model has been widely employed for investigation of immunity to influenza virus infection. In this paper, we review the recent advances in understanding the diminished CD8 T cell immune response to influenza virus infection in aged mice. Possible mechanisms of impaired CD8 T cell responses with aging are addressed, including: (1) the role of dendritic cells (DCs); (2) the effect of age-associated changes in the T cell repertoire; and (3) the interactions with CD4 T cells, including T regulatory (Treg) cells and CD4 T helper cells. The aged murine model of the CD8 T cell response to influenza virus is helping to elucidate the mechanisms of immunosenescence which can lead to therapeutic improvements in the primary CD8 T cell response to new infections, as well as the development of new strategies for immunization to prevent influenza in the elderly.
流感是一种常见的传染病，尤其会侵袭老年人。在对流感病毒感染免疫的研究中，鼠类模型被广泛应用。本文回顾了目前对老年鼠类流感病毒感染中 CD8 T 细胞免疫应答降低的理解进展。探讨了 CD8 T 细胞应答随年龄下降的可能机制，包括：（1）树突状细胞（DC）的作用；（2）T 细胞库随年龄变化的影响；以及（3）与 CD4 T 细胞的相互作用，包括调节性 T 细胞（Treg）和 CD4 辅助性 T 细胞。流感病毒诱导的 CD8 T 细胞反应的老年鼠模型有助于阐明免疫衰老的机制，从而为改善新感染时初始 CD8 T 细胞反应提供治疗手段，并为预防老年人流感制定新的免疫策略。
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