Department of Cell Biology, Okayama University Graduate, School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Exp Dermatol. 2011 Mar;20(3):273-7. doi: 10.1111/j.1600-0625.2010.01244.x.
Dickkopf (Dkk) family members are known as Wnt modulators involved in the development, cell growth/differentiation and cancer. REIC/Dkk-3, which does not interfere with Wnt signalling, has been proposed to be a tumor suppressor gene, but its physiological function has remained unclear. In this study, we analysed the expression of REIC/Dkk-3 in normal interfollicular epidermis (IFE) and hyperproliferative epidermis. REIC/Dkk-3 was expressed in human and mouse IFE, being localized at the interface of upper spinous layer and granular layer. Skin cancer cell lines lost REIC/Dkk-3 expression as reported previously. When we analysed patient samples, REIC/Dkk-3 expression was down-regulated in the hyperproliferative epidermis including skin cancers and non-cancerous proliferative diseases. REIC/Dkk-3 expression was also suppressed in the regenerative and inflammative epidermis of model mice. These findings will certainly contribute to the extension of studies on REIC/Dkk-3.
Dickkopf (Dkk) 家族成员被称为 Wnt 调节剂，参与发育、细胞生长/分化和癌症。REIC/Dkk-3 不干扰 Wnt 信号，被提议为肿瘤抑制基因，但它的生理功能仍不清楚。在这项研究中，我们分析了 REIC/Dkk-3 在正常滤泡间表皮 (IFE) 和过度增殖表皮中的表达。REIC/Dkk-3 在人和小鼠 IFE 中表达，位于上棘突层和颗粒层的界面处。正如先前报道的那样，皮肤癌细胞系丧失了 REIC/Dkk-3 的表达。当我们分析患者样本时，REIC/Dkk-3 的表达在包括皮肤癌和非癌性增殖性疾病在内的过度增殖表皮中下调。REIC/Dkk-3 的表达也在模型小鼠的再生和炎症表皮中受到抑制。这些发现肯定会有助于对 REIC/Dkk-3 研究的扩展。
