Pickup J
King's College London School of Medicine, Guy's Hospital, London, UK.
Int J Clin Pract Suppl. 2011 Feb(170):16-9. doi: 10.1111/j.1742-1241.2010.02574.x.
The last year has seen a continued uptake of insulin pump therapy in most countries. The USA is still a leader in pump use, with probably some 40% of type 1 diabetic patients on continuous subcutaneous insulin infusion (CSII), but the large variation in usage within Europe remains, with relatively high use (> 15%) in, for example, Norway, Austria, Germany and Sweden and low use (< 5%) in Spain, the UK, Finland and Portugal. There is much speculation on the factors responsible for this variation, and the possibilities include physician attitudes to CSII and knowledge about its benefits and indications for its use (and inappropriate beliefs about dangers), the availability of reimbursement from insurance companies or funding from national health services, the availability of sufficient diabetes nurse educators and dietitians trained in pump procedures, and clear referral pathways for the pump candidate from general practitioner or general hospital to specialist pump centre. There are now several comprehensive national guidelines on CSII use (see ATTD Yearbook 2009) but more work needs to be done in unifying uptake and ensuring all those who can benefit do so. Technology developments recently include increasing use of pumps with continuous glucose monitoring (CGM) connectivity (see elsewhere in this volume) and the emergence of numerous manufacturers developing so-called 'patch pumps', often for the type 2 diabetes market. Interestingly, the evidence base for CSII in this group is not well established, and for this reason the selected papers on CSII in this section include several in this area. The use of CSII in diabetic pregnancy is a long-established practice, in spite of the lack of evidence that it is superior to multiple daily injections (MDI), and few randomised controlled trials have been done in recent years. Several papers in this field this year continue the debate about the usefulness of CSII in diabetic pregnancy and are reviewed here. It is pleasing to see more research on the psychosocial aspects of CSII during the year, both from the point of view of how psychological beliefs influence outcomes on CSII (is there a type of patient who does particularly well or poorly on CSII?) and how CSII affects psychological factors like mood, behaviour and quality of life. Quality of life is a difficult topic with doubts that the instruments always capture the aspects of quality of life important to the patient, and there have been conflicting results over the years about whether CSII alters quality of life. Patients in the clinic usually say that it does, and more evidence for quality of life improvement in pump therapy is reviewed here.
去年,大多数国家胰岛素泵疗法的使用持续增加。美国在胰岛素泵的使用方面仍处于领先地位,约40%的1型糖尿病患者采用持续皮下胰岛素输注(CSII),但欧洲各国的使用情况差异依然很大,例如挪威、奥地利、德国和瑞典的使用率相对较高(>15%),而西班牙、英国、芬兰和葡萄牙的使用率较低(<5%)。对于造成这种差异的因素有诸多猜测,可能的因素包括医生对CSII的态度、对其益处及使用指征的了解(以及对风险的不当认知)、保险公司的报销情况或国家医疗服务机构的资金支持、是否有足够数量接受过胰岛素泵操作培训的糖尿病护理教育工作者和营养师,以及从全科医生或综合医院到专业胰岛素泵中心的明确转诊途径。目前已有若干关于CSII使用的全面国家指南(见《2009年ATTD年鉴》),但在统一使用情况并确保所有能从中受益的人都能使用方面,仍需开展更多工作。近期技术发展包括越来越多地使用具备连续血糖监测(CGM)连接功能的胰岛素泵(见本卷其他部分),以及众多制造商推出所谓的“贴片泵”,这类产品通常面向2型糖尿病市场。有趣的是,CSII在这一群体中的证据基础并不完善,因此本节中关于CSII的入选论文包括了该领域的几篇。尽管缺乏证据表明CSII优于多次皮下注射(MDI),但在糖尿病妊娠中使用CSII仍是一种长期做法,近年来进行的随机对照试验很少。今年该领域的几篇论文继续探讨CSII在糖尿病妊娠中的效用,本文对此进行综述。令人欣慰的是,今年有更多关于CSII心理社会方面的研究,既涉及心理信念如何影响CSII的治疗效果(是否存在在CSII治疗中表现特别好或特别差的患者类型?),也涉及CSII如何影响情绪、行为和生活质量等心理因素。生活质量是一个复杂的话题,有人质疑相关工具是否总能涵盖对患者重要的生活质量方面,多年来关于CSII是否改变生活质量也存在相互矛盾的结果。临床患者通常表示CSII能改善生活质量,本文综述了更多关于胰岛素泵疗法改善生活质量的证据。