BODIPY 分子α-氢的间接亲核取代及其在直接乙烯基化反应中的扩展。
Vicarious nucleophilic substitution of α-hydrogen of BODIPY and its extension to direct ethenylation.
机构信息
Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200f, bus 02404, 3001 Leuven, Belgium.
出版信息
Org Lett. 2011 Mar 18;13(6):1470-3. doi: 10.1021/ol200148u. Epub 2011 Feb 18.
PMID:21332155
Abstract
Direct, oxidizer-free substitution of the 3-hydrogen of BODIPY derivatives has been established through a vicarious nucleophilic substitution procedure. This methodology has been combined with a reversible Michael addition on nitrostyrenes to provide a novel, highly efficient entry to the valuable 3-styrylated BODIPY dyes.
摘要
通过替代亲核取代反应程序，建立了直接、无氧化剂取代 BODIPY 衍生物的 3-位氢的方法。这种方法与硝基亚乙烯基上的可逆迈克尔加成反应相结合，为有价值的 3-取代的 BODIPY 染料提供了一种新颖、高效的途径。
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