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对患有原发性青光眼的犬使用艾哈迈德前房角植入物的长期评估:9例病例(2000 - 2008年)

Long-term evaluation of the use of Ahmed gonioimplants in dogs with primary glaucoma: nine cases (2000-2008).

作者信息

Westermeyer Hans D, Hendrix Diane V H, Ward Daniel A

机构信息

Department of Small Animal Clinical Sciences, University of Tennessee, Knoxville, TN 37996, USA.

出版信息

J Am Vet Med Assoc. 2011 Mar 1;238(5):610-7. doi: 10.2460/javma.238.5.610.

Abstract

OBJECTIVE

To evaluate the outcome and describe the complications associated with use of an Ahmed gonioimplant in the treatment of glaucoma in dogs.

DESIGN

Retrospective case series.

ANIMALS

9 client-owned sighted dogs (median age, 9 years) with primary glaucoma. Procedures-Medical records of dogs with primary glaucoma that underwent unilateral gonioimplant placement (in 2000 through 2008), during which a temporalis muscle fascia graft (n = 8) or porcine intestinal submucosa (1) was used to cover the implant tube as it exited the globe, were reviewed. All dogs were treated with mitomycin C in the conjunctival pocket intraoperatively and with tissue plasminogen activator immediately after surgery; 1% prednisolone acetate was applied to the implanted eye daily until failure of the implant. Medical intervention or additional surgery was performed when intraocular pressures (IOPs) were > 20 mm Hg or progressively increasing values were detected.

RESULTS

After gonioimplant placement, IOP was controlled for a variable period in all dogs. Subsequently, IOP exceeded 20 mm Hg in 7 dogs (median postoperative interval, 326 days). Median interval to vision loss despite interventional surgery was 518 days (range, 152 to 1,220 days). Surgical intervention was necessary in 4 dogs to maintain satisfactory IOP. Implant extrusion attributable to conjunctival dehiscence or necrosis occurred in 4 dogs. At 365 days after surgery, 8 dogs retained vision, and 5 dogs retained vision throughout follow-up.

CONCLUSIONS AND CLINICAL RELEVANCE

In dogs with medically refractory primary glaucoma, placement of a gonioimplant appears to be effective in maintaining vision.

摘要

目的

评估使用艾哈迈德前房植入物治疗犬青光眼的疗效,并描述相关并发症。

设计

回顾性病例系列研究。

动物

9只患有原发性青光眼的客户拥有的视力正常犬(中位年龄9岁)。

方法

回顾2000年至2008年期间接受单侧前房植入物植入的原发性青光眼犬的病历,植入时8只使用颞肌筋膜移植物、1只使用猪小肠黏膜下层覆盖植入管穿出眼球处。所有犬术中在结膜囊内使用丝裂霉素C,术后立即使用组织纤溶酶原激活剂;植入眼每日应用1%醋酸泼尼松龙直至植入物失效。当眼压>20mmHg或眼压持续升高时进行药物干预或再次手术。

结果

植入前房植入物后,所有犬的眼压在不同时间段得到控制。随后,7只犬的眼压超过20mmHg(术后中位间隔时间326天)。尽管进行了手术干预,但视力丧失的中位间隔时间为518天(范围152至1220天)。4只犬需要进行手术干预以维持眼压在满意水平。4只犬因结膜裂开或坏死导致植入物脱出。术后365天时,8只犬保留视力,5只犬在整个随访过程中保留视力。

结论及临床意义

对于药物治疗无效的犬原发性青光眼,植入前房植入物似乎对维持视力有效。

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