在小鼠和灵长类动物中进行DNA疫苗的肌肉注射和皮内注射。
Intramuscular and intradermal injection of DNA vaccines in mice and primates.
作者信息
Davis H L
机构信息
Ottawa Civic Hospital, Ottawa, Ontario, Canada.
出版信息
Methods Mol Med. 2000;29:71-7. doi: 10.1385/1-59259-688-6:71.
PMID:21374310
Abstract
There are several different ways to administer plasmid DNA vaccines (1). Those most commonly used include intramuscular (i.m.) injection or intradermal (i.d.) injection of pure plasmid DNA ("naked" DNA), or biolistic introduction of DNA-coated gold particles into the epidermis with a "gene gun." It is also possible to deliver naked or liposome-formulated DNA to mucosal surfaces.
摘要
有几种不同的方式来施用质粒DNA疫苗(1)。最常用的方法包括肌内(i.m.)注射或皮内(i.d.)注射纯质粒DNA(“裸”DNA)，或者用“基因枪”将包被有DNA的金颗粒通过生物弹道法导入表皮。将裸DNA或脂质体形式的DNA递送至粘膜表面也是可行的。
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