Pulmonary and Critical Care Division, PBB Clinics 3, 75 Francis Street, Boston, MA 02115, USA.
J Breath Res. 2010 Dec;4(4):047001. doi: 10.1088/1752-7155/4/4/047001. Epub 2010 Nov 30.
Exhaled breath condensate (EBC) collection and analysis offers a unique non-invasive method to sample the airway lining fluid. It enables classification and quantification of airway inflammation associated with various pulmonary diseases such as asthma. Over the last decade, innumerable efforts have been made to identify biomarkers in EBC for diagnosis and management of asthma. The aim of this review is to consolidate information available to date, summarize findings from studies and identify potential biomarkers which need further refinement through translational research prior to application in clinical practice.
呼出气冷凝物(EBC)的收集和分析提供了一种独特的非侵入性方法来采样气道衬液。它能够对与各种肺部疾病(如哮喘)相关的气道炎症进行分类和定量。在过去的十年中,人们已经做出了无数努力来鉴定 EBC 中的生物标志物,以用于哮喘的诊断和管理。本综述的目的是整合目前已有的信息,总结研究结果,并确定需要通过转化研究进一步完善以应用于临床实践的潜在生物标志物。