[聚阴离子的抗肿瘤活性及其在抗肿瘤药物递送系统中的应用]
[Antitumor activity of polyanion and its application for drug delivery system of antitumor drugs].
作者信息
Hirano T, Ohashi S, Todoroki T, Inaba M, Tsukagoshi S
机构信息
Dept. of Bioengineering, University of Tsukuba.
出版信息
Gan To Kagaku Ryoho. 1990 Mar;17(3 Pt 2):542-7.
Polyanionid copolymer of divinyl ether and maleic anhydride (DIVEMA) with narrow molecular weight distribution was synthesized and tested of its antitumor activity. DIVEMA showed a significant antitumor activity against colon 26 adenocarcinoma and FSaI fibrosarcoma transplanted in syngenic mice. Furthermore, DIVEMA was used as a polymeric drug carrier of antitumor drugs to reduce side effects and enhance the antitumor activity of the drugs. Adriamycin and neocarzinostatin were attached covalently to DIVEMA and the polymeric conjugates showed higher antitumor activity than the corresponding mother drugs against P 388 leukemic mice.
合成了具有窄分子量分布的二乙烯基醚与马来酸酐的聚阴离子共聚物（DIVEMA），并对其抗肿瘤活性进行了测试。DIVEMA对移植于同基因小鼠体内的结肠26腺癌和FSaI纤维肉瘤显示出显著的抗肿瘤活性。此外，DIVEMA被用作抗肿瘤药物的聚合物载体，以减少副作用并增强药物的抗肿瘤活性。阿霉素和新制癌菌素被共价连接到DIVEMA上，并且该聚合物偶联物对P 388白血病小鼠显示出比相应母体药物更高的抗肿瘤活性。
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