鉴定与依赖相关的过量乙醇摄入引起的小鼠延伸杏仁核中受调控的基因。
Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence.
机构信息
The Scripps Research Institute, Committee on the Neurobiology of Addictive Disorders, La Jolla, CA 92037, USA.
出版信息
Addict Biol. 2011 Oct;16(4):615-9. doi: 10.1111/j.1369-1600.2010.00304.x. Epub 2011 Mar 11.
Abstract
Alcoholism is characterized by a progressive loss of control over ethanol intake. The purpose of this study was to identify transcriptional changes selectively associated with excessive ethanol drinking in dependent mice, as opposed to non-dependent mice maintaining a stable voluntary consumption or mice solely undergoing forced intoxication. We measured expression levels of 106 candidate genes in the extended amygdala, a key brain structure for the development of drug addiction. Cluster analysis identified 17 and 15 genes selectively induced or repressed, respectively, under conditions of excessive drinking. These genes belong to signaling pathways involved in neurotransmission and transcriptional regulation.
摘要
酒精中毒的特点是对乙醇摄入的控制逐渐丧失。本研究的目的是鉴定与依赖小鼠过度饮酒选择性相关的转录变化，而不是与维持稳定自愿饮酒的非依赖小鼠或仅经历强制中毒的小鼠。我们测量了扩展杏仁核中 106 个候选基因的表达水平，扩展杏仁核是药物成瘾发展的关键脑结构。聚类分析分别确定了 17 个和 15 个分别受诱导或抑制的基因。这些基因属于涉及神经递质传递和转录调节的信号通路。
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