从内生真菌曲霉属HS-05中分离得到的两种新化合物。
Two new compounds from an endophytic fungus Aspergillus sp. HS-05.
作者信息
Zhang Lin, Chen Gang, Wu Hong-Hua, Lu Xuan, Pei Yue-Hu, Wu Xin, Pan Bo, Hua Hui-Ming, Bai Jiao
机构信息
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
出版信息
J Asian Nat Prod Res. 2011 Mar;13(3):225-9. doi: 10.1080/10286020.2010.550885.
Two new compounds, N-[4'-hydroxy-(E)-cinnamoyl]-l-tyrosine methyl ester (1) and methyl 4-methoxy-3-(3'-hydroxy-2'-methyl)propionyloxy-benzoate (2), were isolated from EtOAc extract of the fermentation broth of the endophytic fungus Aspergillus sp. HS-05. Their structures were elucidated by NMR, IR, UV, MS, and CD methods. Compounds 1 and 2 showed no anticancer activities against HL-60 cell lines (both of IC(50)>100 μM) in vitro.
从内生真菌曲霉属HS-05发酵液的乙酸乙酯提取物中分离出两种新化合物，N-[4'-羟基-(E)-肉桂酰基]-L-酪氨酸甲酯(1)和4-甲氧基-3-(3'-羟基-2'-甲基)丙酰氧基苯甲酸甲酯(2)。通过核磁共振、红外光谱、紫外光谱、质谱和圆二色光谱法对其结构进行了鉴定。化合物1和2在体外对HL-60细胞系均无抗癌活性(半数抑制浓度均>100 μM)。
Zotero 插件