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乳腺癌患者的生育力保护

Fertility conservation in breast cancer patients.

作者信息

Lawrenz Barbara, Henes Melanie, Neunhoeffer Eva, Kraemer Bernhard, Fehm Tanja

机构信息

Department of Obstetrics & Gynaecology, University Hospital for Women, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany.

出版信息

Womens Health (Lond). 2011 Mar;7(2):203-12. doi: 10.2217/whe.10.91.

Abstract

Breast cancer is the most common malignant tumor in women. Increasing survival rates after breast cancer, new reproductive techniques and growing interest regarding the quality of life after cancer have brought the possibilities of fertility-preserving treatment to the center of attention of oncologists and affected patients. Many of these women suffer from infertility and premature menopause as a result of chemotherapy. Several measures, for example gonadotropin-releasing hormone analogs, hormonal stimulation to cryopreserve oocytes, ovarian tissue cryoconservation or a combination of the methods, can be undertaken depending on the hormone receptor status of the tumor, and the patient's age and partner status. Embryo cryopreservation is currently the most promising fertility preservation option. Early counseling on fertility-preserving strategies is of utmost importance, so that the fertility-preserving method can be integrated into the oncologic therapy regime.

摘要

乳腺癌是女性最常见的恶性肿瘤。乳腺癌生存率的提高、新的生殖技术以及人们对癌症后生活质量日益增长的关注,使得保留生育功能治疗的可能性成为肿瘤学家和受影响患者关注的焦点。这些女性中的许多人因化疗而遭受不孕和过早绝经之苦。根据肿瘤的激素受体状态、患者年龄和伴侣状况,可以采取多种措施,例如促性腺激素释放激素类似物、激素刺激以冷冻保存卵母细胞、卵巢组织冷冻保存或这些方法的组合。胚胎冷冻保存目前是最有前景的保留生育功能选择。尽早就保留生育功能策略进行咨询至关重要,以便将保留生育功能的方法纳入肿瘤治疗方案。

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