HLA-DRB1 基因座与中国人群梅毒的关联性。

Association of the HLA-DRB1 locus with syphilis in a Chinese population.

机构信息

Shandong Provincial Institute of Dermatology and Venereology, Provincial Academy of Medical Science, Shandong Province, China.

出版信息

Int J Infect Dis. 2011 May;15(5):e342-5. doi: 10.1016/j.ijid.2011.01.008. Epub 2011 Mar 15.

DOI:10.1016/j.ijid.2011.01.008

PMID:21411354

Abstract

BACKGROUND

Syphilis is a sexually transmitted infection (STI) caused by the Treponema pallidum subspecies pallidum spirochete bacterium. The association of human leukocyte antigen (HLA) with syphilis has been reported in several populations, but not in the Chinese population. Furthermore, serology methods have mostly been used in previous studies investigating the association between STIs and HLA alleles. The objective of this study was to analyze the association of the HLA-DRB1 alleles and susceptibility to syphilis in the Chinese population.

METHODS

A polymerase chain reaction with sequence-specific primers (PCR-SSP) method was used to genotype HLA-DRB1 alleles in 196 syphilis patients and 500 healthy controls.

RESULTS

The HLA-DRB1*14 allele was more prevalent in syphilis patients than in the healthy controls (p=0.013; corrected p<0.05).

CONCLUSIONS

The allele HLA-DRB1*14 was found to be associated with susceptibility to syphilis in the Chinese population.

摘要

背景

梅毒是一种由苍白密螺旋体亚种苍白密螺旋体引起的性传播感染（STI）。人类白细胞抗原（HLA）与梅毒的关联已在多个人群中得到报道，但在中国人群中尚未报道。此外，在以前研究 STI 与 HLA 等位基因之间的关联的研究中，主要使用血清学方法。本研究旨在分析 HLA-DRB1 等位基因与中国人群梅毒易感性的关联。