新型二氢嘧啶类及其吡唑衍生物的合成与药理筛选。
Novel dihydropyrimidines and its pyrazole derivatives: synthesis and pharmacological screening.
机构信息
Department of Pharmaceutical Chemistry, S.A.C. College of Pharmacy, B.G. Nagara 571448, Nagamangala (tq), Mandya (dist), Karnataka, India.
出版信息
Eur J Med Chem. 2011 May;46(5):1882-91. doi: 10.1016/j.ejmech.2011.02.052. Epub 2011 Feb 26.
In the present study, we have synthesized novel dihydropyrimidines (1a-j), their dimethylated adducts (2a-j), and hydrazine derivatives (3a-j) of 2a-j and subsequently their pyrazole derivatives (4a-j). Elemental analysis, IR, 1H NMR and mass spectral data elucidated structure of newly synthesized compounds. Some of these novel derivatives showed moderate to potent in vitro antioxidant, anti-inflammatory, antibacterial, antifungal and anthelmintic activity.
在本研究中，我们合成了新型的二氢嘧啶（1a-j）、它们的二甲加成物（2a-j）以及它们的肼衍生物（3a-j），随后还合成了它们的吡唑衍生物（4a-j）。元素分析、IR、1H NMR 和质谱数据阐明了新合成化合物的结构。这些新型衍生物中的一些表现出中等至较强的体外抗氧化、抗炎、抗菌、抗真菌和驱虫活性。
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