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生育力保护作为一个公共卫生问题:从流行病学角度来看。

Fertility preservation as a public health issue: an epidemiological perspective.

机构信息

Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA.

出版信息

Curr Opin Obstet Gynecol. 2011 Jun;23(3):143-50. doi: 10.1097/GCO.0b013e3283455270.

Abstract

PURPOSE OF REVIEW

Over the past decade, fertility preservation has become an increasingly viable option for patients diagnosed with diseases such as cancer and systemic lupus erythematosus (SLE), whose treatment often results in impaired fertility. This review summarizes current epidemiological trends that have caused cancer-related and SLE-related infertility to be an important and growing public health burden, which may be reduced by improving access to fertility preservation services.

RECENT FINDINGS

In the United States alone, over 130 000 men and women below the age of 45 were afflicted by cancer in 2008. The compromised fertility that will be faced by many of these patients can result in significant psychosocial stress and reduced quality of life, even long after the disease has been successfully treated. Although the use of fertility preservation services may help alleviate this burden, access to these services is often inadequate, because of logistical barriers and a lack of appropriate patient referral by healthcare providers.

SUMMARY

Increases in cancer survival rates and the average age at which a mother will have her first child has put added emphasis on the need for fertility preservation services. Enhanced provider and patient education, as well improved coordination of oncological-reproductive care, may promote patient access to fertility preservation services.

摘要

目的综述:在过去十年中,生育力保存已成为癌症和系统性红斑狼疮(SLE)等疾病患者的一种可行选择,这些疾病的治疗通常会导致生育力受损。本综述总结了目前的流行病学趋势,这些趋势使得癌症相关和 SLE 相关的不孕成为一个重要且日益严重的公共卫生负担,通过改善获得生育力保存服务的机会,可能会减轻这一负担。

最近的发现:仅在美国,2008 年就有超过 130000 名 45 岁以下的男性和女性患有癌症。这些患者中的许多人会面临生育能力受损的问题,这可能会导致严重的心理社会压力和生活质量下降,即使在疾病得到成功治疗很久之后也是如此。尽管使用生育力保存服务可能有助于减轻这一负担,但由于后勤障碍和医疗保健提供者缺乏适当的患者转介,这些服务的获得往往不足。

总结:癌症存活率的提高和初产妇的平均年龄的增加,使得对生育力保存服务的需求更加迫切。加强对提供者和患者的教育,以及改善肿瘤-生殖护理的协调,可能会促进患者获得生育力保存服务。

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