Zhang Jun, Qi Juan, Guo Yan, Guo Yi, Fu Weineng, Zhou Baosen, Wu Guangping, Han Libo, He Anguang
China Medical University Lung Cancer Center, the First Hospital of China Medical University, Shenyang, China.
Zhongguo Fei Ai Za Zhi. 2011 Mar;14(3):211-8. doi: 10.3779/j.issn.1009-3419.2011.03.06.
Our previous studies revealed that hepatoma-derived growth factor (HDGF) is highly expressed in non-small cell lung cancer (NSCLC) cells, playing important roles in promoting NSCLC cells growth and invasion. The aim of this study is to detect the expression of HDGF in 158 cases of surgically resected NSCLC and evaluate its clinical significance.
Immunohistochemical SP method was used to detect the expression of HDGF in 158 NSCLC tissues and 12 normal control lung tissues. Survival analysis was further conducted.
HDGF was found significantly highly expressed in 158 NSCLC tissues compared with normal control lung tissues (P < 0.001). The 5-year survival rate was 38.2% in HDGF high expression cases, compared with 63.1% in HDGF low expression cases, the difference was statistically significant (P=0.009). Linear correlation analysis discovered a significantly negative correlation between HDGF expression and the survival time (r=-0.183, P=0.022). COX proportion hazard model analysis revealed that pathological stages and HDGF expression were independent prognostic factors for this group of 158 resected NSCLC cases.
HDGF is highly expressed in human NSCLC tissues, predicting worse prognosis in resected NSCLCs. It might be useful molecular biomarker for predicting the prognosis of resected NSCLCs.
我们之前的研究表明，肝癌衍生生长因子（HDGF）在非小细胞肺癌（NSCLC）细胞中高表达，在促进NSCLC细胞生长和侵袭中发挥重要作用。本研究旨在检测158例手术切除的NSCLC中HDGF的表达，并评估其临床意义。
采用免疫组织化学SP法检测158例NSCLC组织和12例正常对照肺组织中HDGF的表达。进一步进行生存分析。
与正常对照肺组织相比，HDGF在158例NSCLC组织中显著高表达（P < 0.001）。HDGF高表达病例的5年生存率为38.2%，而HDGF低表达病例为63.1%，差异有统计学意义（P = 0.009）。线性相关分析发现HDGF表达与生存时间呈显著负相关（r = -0.183，P = 0.022）。COX比例风险模型分析显示，病理分期和HDGF表达是这158例切除的NSCLC病例的独立预后因素。
HDGF在人NSCLC组织中高表达，提示切除的NSCLC预后较差。它可能是预测切除的NSCLC预后的有用分子生物标志物。
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