宿主种群中罗斯河病毒内多个遗传谱系的持续存在。
Persistence of multiple genetic lineages within intrahost populations of Ross River virus.
机构信息
Australian Army Malaria Institute, Brisbane, Australia.
出版信息
J Virol. 2011 Jun;85(11):5674-8. doi: 10.1128/JVI.02622-10. Epub 2011 Mar 23.
Abstract
We examined the structure and extent of genetic diversity in intrahost populations of Ross River virus (RRV) in samples from six human patients, focusing on the nonstructural (nsP3) and structural (E2) protein genes. Strikingly, although the samples were collected from contrasting ecological settings 3,000 kilometers apart in Australia, we observed multiple viral lineages in four of the six individuals, which is indicative of widespread mixed infections. In addition, a comparison with previously published RRV sequences revealed that these distinct lineages have been in circulation for at least 5 years, and we were able to document their long-term persistence over extensive geographical distances.
摘要
我们研究了来自六个病人的罗斯河病毒（RRV）在宿主内种群的结构和遗传多样性，重点关注非结构（nsP3）和结构（E2）蛋白基因。惊人的是，尽管这些样本是在澳大利亚相距 3000 公里的不同生态环境中采集的，但我们在其中四个个体中观察到了多种病毒谱系，这表明存在广泛的混合感染。此外，与以前发表的 RRV 序列的比较表明，这些不同的谱系已经流行了至少 5 年，我们能够记录它们在广泛的地理距离上的长期持续存在。
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