新加坡儿童中与家庭内内毒素和β-葡聚糖暴露有关的中耳炎、鼻炎和特应性。
Otitis, rhinitis, and atopy in relation to domestic endotoxin and β-glucan exposure among children in Singapore.
机构信息
Department of Otolaryngology, National University of Singapore, National University Hospital, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore.
出版信息
Environ Health Prev Med. 2010 Sep;15(5):271-5. doi: 10.1007/s12199-010-0137-2. Epub 2010 Apr 2.
BACKGROUND
Exposure to microbial cell wall agents (MCWAs) has been related to the risk for atopy, otitis, and rhinitis.
OBJECTIVES
To relate domestic exposure to two important MCWAs-β-glucan and endotoxin-to the risk for otitis, rhinitis, atopy, and allergy in a sample of children from Singapore.
METHODS
Subjects (n = 98) were recruited from July 2006 to December 2008. Blood samples were taken to determine nonspecific IgE and skin prick tests were performed. Dust samples were collected from the bedrooms of the subjects and analyzed for the content of β-glucan and endotoxin, using the Limulus method.
RESULTS
Levels of IgE were significantly higher among children with rhinitis, and these children also had a larger proportion of atopics. There were no differences in β-glucan values between children with otitis, children with rhinitis, and controls. Endotoxin levels were lower in the homes of children with otitis, with a tendency for the levels to be lower in those with rhinitis. Among children with a high level of β-glucan, there was a higher proportion of those with high IgE values and atopy.
CONCLUSIONS
The results suggest that a low level of endotoxin is a risk factor for otitis and that a high level of β-glucan is a risk factor for atopic sensitisation. Reactions to domestic indoor exposure are determined by several indoor agents and their relative exposure levels.
背景
接触微生物细胞壁成分（MCWAs）与特应性、中耳炎和鼻炎的风险有关。
目的
在新加坡的儿童样本中，将家庭接触两种重要的 MCWAs-β-葡聚糖和内毒素与中耳炎、鼻炎、特应性和过敏的风险联系起来。
方法
从 2006 年 7 月至 2008 年 12 月招募了研究对象（n=98）。采集血样以确定非特异性 IgE，并进行皮肤点刺试验。从研究对象的卧室收集灰尘样本，并使用鲎试剂法分析β-葡聚糖和内毒素的含量。
结果
患有鼻炎的儿童 IgE 水平明显更高，而且这些儿童的特应性比例也更高。中耳炎儿童与鼻炎儿童和对照组之间β-葡聚糖值没有差异。中耳炎儿童家中的内毒素水平较低，鼻炎儿童的内毒素水平也有降低的趋势。在β-葡聚糖水平较高的儿童中，高 IgE 值和特应性的比例较高。
结论
结果表明，低水平的内毒素是中耳炎的危险因素，高水平的β-葡聚糖是特应性致敏的危险因素。室内暴露的室内反应由几种室内剂及其相对暴露水平决定。
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