光动力疗法的免疫抑制作用。
The immunosuppressive side of PDT.
机构信息
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.
出版信息
Photochem Photobiol Sci. 2011 May;10(5):751-8. doi: 10.1039/c0pp00345j. Epub 2011 Mar 24.
Abstract
Photodynamic therapy (PDT) is a promising novel therapeutic procedure for the management of a variety of solid tumors and many non-malignant diseases. PDT has been described as having a significant effect on the immune system, which may be either immunostimulatory or, in some circumstances, immunosuppressive. The immunosuppressive effects of PDT have nearly all been concerned with the suppression of the contact hypersensitivity reaction in mice. Here, we review the immunosuppressive aspects of PDT treatment and discuss some additional mechanisms that may be involved.
摘要
光动力疗法 (PDT) 是一种有前途的新型治疗方法，可用于治疗多种实体瘤和许多非恶性疾病。PDT 已被描述为对免疫系统具有显著影响，这种影响既可以是免疫刺激作用，也可以在某些情况下是免疫抑制作用。PDT 的免疫抑制作用几乎全部与抑制小鼠的接触性过敏反应有关。在此，我们综述 PDT 治疗的免疫抑制方面，并讨论可能涉及的一些其他机制。
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