[Morphological analysis of bone dynamics and metabolic bone disease. Histological findings in animal fracture model--effects of osteoporosis treatment drugs on fracture healing process].

Recently choice of osteoporosis treatment drug in view of fracture healing is getting important because osteoporotic patients under treatment often suffer fragility fractures. Based on our results using animal fracture model, we reviewed radiological, histological and mechanical fracture healing process. Anti-resorptive agents, such as bisphosphonates, do not disturb fracture union and increase mechanical strength of fracture site by increased callus volume, however, they delay fracture healing process especially in restoration of original bony shape and quality in response to the extent of suppressed callus remodeling. In contrast, bone forming agents, such as PTH, shorten natural fracture healing process including restoration of original bony shape or bone quality due to acceleration of callus remodeling.