Department of Epidemiology and Surveillance, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, RIVM, Postbox 1, 3720 BA Bilthoven, the Netherlands.
BMC Infect Dis. 2011 Apr 5;11:85. doi: 10.1186/1471-2334-11-85.
In the Netherlands, incidence of physician's consultations and hospitalizations for varicella is low compared to other countries. Better knowledge about the severity of varicella among Dutch hospitalized patients is needed. Therefore, a medical record research was conducted among hospitalized patients with diagnosis varicella.
Hospital admissions due to varicella in 2003-2006 were obtained from the National Medical Register. Retrospectively, additional data were retrieved from the medical record of patients hospitalized with varicella in 23 Dutch hospitals using a standardized form. Analyses were performed using descriptive statistics.
The study population (N = 296) was representative for all varicella admissions in the Netherlands (N = 1,658) regarding age, sex, duration of admission and type of diagnosis. Complications were recorded in 76% of the patients (37% had at least one relatively severe complication). Bacterial super infections of skin lesions (28%), (imminent) dehydration (19%), febrile convulsions (7%), pneumonia (7%) and gastroenteritis (7%) were most frequently reported. No varicella-related death occurred within the study population and 3% of the patients had serious rest symptoms.
It is not likely that the severity of varicella among hospitalized patients in the Netherlands differs from other countries. A considerable part of the varicella complications among hospitalized patients was rather moderate and can be treated effectively, although in a third of the hospitalized cases with complications, severe complications occurred. These data are relevant in the decision-making process regarding whether or not to introduce routine varicella vaccination in the Netherlands.
与其他国家相比,荷兰的医生就诊和因水痘住院的发病率较低。因此,需要更好地了解荷兰住院水痘患者的严重程度。因此,对诊断为水痘的住院患者进行了病历研究。
从国家医疗登记处获得了 2003-2006 年因水痘住院的住院人数。使用标准化表格从荷兰 23 家医院的水痘住院患者的病历中回顾性地检索了更多数据。使用描述性统计方法进行分析。
研究人群(N = 296)在年龄、性别、住院时间和诊断类型方面代表了荷兰所有水痘住院患者(N = 1658)。76%的患者记录了并发症(37%至少有一种相对严重的并发症)。最常报告的并发症有皮肤病变的细菌超感染(28%)、(即将发生)脱水(19%)、热性惊厥(7%)、肺炎(7%)和胃肠炎(7%)。研究人群中未发生与水痘相关的死亡,3%的患者有严重的后遗症。
荷兰住院水痘患者的严重程度与其他国家可能没有差异。住院水痘患者的并发症相当一部分是中度的,可以有效治疗,尽管在三分之一的并发症住院病例中,严重并发症发生。这些数据对于是否在荷兰引入常规水痘疫苗接种的决策过程中具有重要意义。