绵羊牛海绵状脑病与瘙痒病的分子鉴别。
Molecular discrimination of sheep bovine spongiform encephalopathy from scrapie.
机构信息
Istituto Superiore di Sanita, Rome, Italy.
出版信息
Emerg Infect Dis. 2011 Apr;17(4):695-8. doi: 10.3201/eid1704.101215.
Abstract
Sheep CH1641-like transmissible spongiform encephalopathy isolates have shown molecular similarities to bovine spongiform encephalopathy (BSE) isolates. We report that the prion protein PrPSc from sheep BSE is extremely resistant to denaturation. This feature, combined with the N-terminal PrPSc cleavage, allowed differentiation of classical scrapie, including CH1641-like, from natural goat BSE and experimental sheep BSE.
摘要
绵羊 CH1641 样传染性海绵状脑病分离株与牛海绵状脑病（BSE）分离株表现出分子相似性。我们报告称，绵羊 BSE 的朊病毒蛋白 PrPSc 对变性具有极强的抵抗力。这一特征，加上 N 端 PrPSc 切割，使得包括 CH1641 样在内的经典羊瘙痒病与天然山羊 BSE 和实验绵羊 BSE 得以区分。
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