男性前列腺癌、非典型小腺泡增生与无前列腺癌或非典型小腺泡增生患者的下丘脑-垂体-睾丸轴激素的血清水平。

Serum levels of hypothalamic-pituitary-testicular axis hormones in men with or without prostate cancer or atypical small acinar proliferation.

机构信息

Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil.

出版信息

Clinics (Sao Paulo). 2011;66(2):183-7. doi: 10.1590/s1807-59322011000200001.

DOI:10.1590/s1807-59322011000200001

PMID:21484031

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3059861/

Abstract

INTRODUCTION

Substantial controversy exists regarding the association between testosterone serum levels and prostate cancer.

OBJECTIVE

To evaluate the levels of hypothalamic-pituitary-testicular axis hormones in the sera of men with prostate cancer and atypical small acinar proliferation as well as those with normal biopsies.

METHODS

A study cohort of 186 men with suspected prostate cancer who had undergone transrectal prostate biopsies was used in this study. The patients were divided into the following three groups based on the histology of the biopsy samples: no neoplasia, atypical small acinar proliferation or prostate cancer. Demographic data were also collected. Levels of total testosterone, follicle-stimulating hormone, luteinizing hormone, prolactin, estradiol, and serum prostate-specific antigen were measured in blood samples.

RESULTS

Initially, 123 men were found to be without neoplasia, 26 with atypical small acinar proliferation and 37 with prostate cancer. After a second biopsy was taken from the men diagnosed with atypical small acinar proliferation, the diagnoses were revised: 18 were diagnosed with atypical small acinar proliferation and 45 with prostate cancer. No significant differences between the groups were identified regarding age, smoking history, chronic diseases, body mass index or PSA levels (P >.0.05). The mean serum levels of testosterone, follicle-stimulating hormone, luteinizing hormone, prolactin and estradiol were similar in all of the groups (P >.0.05). Furthermore, in individuals with prostate cancer, the Gleason scores and prevalence of hypogonadism were not significantly different (P.> 0.05).

CONCLUSION

The present study revealed no difference in the serum levels of testosterone, follicle-stimulating hormone, luteinizing hormone, prolactin or estradiol in men without neoplasia compared with those with atypical small acinar proliferation or prostate cancer.

摘要

简介

关于血清睾酮水平与前列腺癌之间的关联存在很大争议。

目的

评估患有前列腺癌和非典型小腺泡增生以及正常活检的男性的下丘脑-垂体-睾丸轴激素水平。

方法

本研究使用了 186 名经直肠前列腺活检怀疑患有前列腺癌的患者作为研究队列。根据活检样本的组织学，将患者分为以下三组：无肿瘤、非典型小腺泡增生或前列腺癌。还收集了人口统计学数据。测量了血液样本中总睾酮、卵泡刺激素、黄体生成素、催乳素、雌二醇和血清前列腺特异性抗原的水平。

结果

最初，发现 123 名男性无肿瘤，26 名男性患有非典型小腺泡增生，37 名男性患有前列腺癌。对被诊断为非典型小腺泡增生的男性进行第二次活检后，诊断结果被修订：18 名男性被诊断为非典型小腺泡增生，45 名男性被诊断为前列腺癌。各组之间在年龄、吸烟史、慢性疾病、体重指数或 PSA 水平方面无显著差异（P >.05）。所有组的血清睾酮、卵泡刺激素、黄体生成素、催乳素和雌二醇水平均相似（P >.05）。此外，在患有前列腺癌的个体中，Gleason 评分和性腺功能减退症的患病率无显著差异（P >.05）。