核黄素类似物和利尿剂对自发性高血压大鼠心脏的影响。

Effects of riboflavin analogues and diuretics on the spontaneously hypertensive rat heart.

作者信息

Bhaskar M, Trachewsky D, Stith R D, Reddy Y S

机构信息

Department of Physiology and Biophysics, University of Oklahoma Health Sciences Center, Oklahoma City.

出版信息

Basic Res Cardiol. 1990 Sep-Oct;85(5):444-52. doi: 10.1007/BF01931490.

DOI:10.1007/BF01931490

PMID:2148869

Abstract

The chronic treatment of spontaneously hypertensive rats (SHR) with 7,8-dimethyl-10-(3-chlorobenzyl) isoalloxazine [CBI], 7,8-diethyl-10-aminol isoalloxazine [DEAI], enduron (methyclothiazide) and amiloride were studied for their effects on blood pressure and cardiac contractile protein ATPase activities. After 35 weeks of treatment all the above antihypertensive agents showed a decrease in blood pressure in the SHR (p less than 0.01). Chronic treatment with CBI, DEAI, enduron, and amiloride significantly improved the myofibrillar ATPase activity at all pCa2+ concentrations (p less than 0.01). Furthermore, CBI, DEAI, enduron, and amiloride drug treatments enhanced actin-activated myosin ATPase activity (p less than 0.01). The Ca2(+)-activated myosin ATPase activity was significantly elevated after treating with CBI and DEAI (p less than 0.01). These results suggest that the antihypertensive agents used in this study helped in reducing the blood pressure with a subsequent increase in myocardial contractile protein ATPase activity.

摘要

研究了用7,8-二甲基-10-(3-氯苄基)异咯嗪[CBI]、7,8-二乙基-10-氨基异咯嗪[DEAI]、速尿（甲氯噻嗪）和氨氯吡咪对自发性高血压大鼠（SHR）进行长期治疗时，它们对血压和心肌收缩蛋白ATP酶活性的影响。治疗35周后，上述所有抗高血压药物均使SHR的血压下降（p<0.01）。用CBI、DEAI、速尿和氨氯吡咪进行长期治疗可在所有pCa2+浓度下显著改善肌原纤维ATP酶活性（p<0.01）。此外，CBI、DEAI、速尿和氨氯吡咪药物治疗增强了肌动蛋白激活的肌球蛋白ATP酶活性（p<0.01）。用CBI和DEAI治疗后，Ca2+激活的肌球蛋白ATP酶活性显著升高（p<0.01）。这些结果表明，本研究中使用的抗高血压药物有助于降低血压，随后心肌收缩蛋白ATP酶活性增加。