慢性疼痛和丙型肝炎病毒感染在阿片类药物依赖的注射吸毒者中。
Chronic pain and hepatitis C virus infection in opioid dependent injection drug users.
机构信息
Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA.
出版信息
J Addict Dis. 2011 Apr;30(2):91-7. doi: 10.1080/10550887.2011.554775.
Abstract
It is unknown whether infection with hepatitis C is a risk factor for pain among people who have used injection drugs. Multivariate regression was used to determine whether hepatitis C was associated with greater likelihood of reporting significant chronic pain and discomfort intolerance in a cohort of 97 injection drug users dependent on opioids. Study results suggest that participants with hepatitis C may be more likely to experience chronic pain (aOR=1.98; 95% confidence interval=0.76 to 5.12, p=0.16). Furthermore, hepatitis C was found to be associated with a higher discomfort intolerance scale score, reflecting intolerance to physical discomfort (β=2.34; 95% confidence interval=0.06 to 4.62; p=0.04). Hepatitis C may be a cause for chronic pain and discomfort intolerance that is overlooked among injection drug users dependent on opioids.
摘要
目前尚不清楚丙型肝炎感染是否是使用注射毒品者出现疼痛的一个风险因素。采用多元回归分析，在一个依赖阿片类药物的 97 名注射吸毒者队列中，确定丙型肝炎是否与报告显著慢性疼痛和不适不耐受的可能性更大相关。研究结果表明，丙型肝炎感染者可能更容易出现慢性疼痛（优势比=1.98；95%置信区间=0.76 至 5.12，p=0.16）。此外，丙型肝炎与更高的不适耐受量表评分相关，这反映了对身体不适的不耐受（β=2.34；95%置信区间=0.06 至 4.62；p=0.04）。丙型肝炎可能是阿片类药物依赖的注射吸毒者慢性疼痛和不适不耐受的一个被忽视的原因。
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