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斜坡原发性脑膜 T 细胞淋巴瘤,酷似脑膜瘤。

Primary meningeal T-cell lymphoma at the clivus mimicking a meningioma.

机构信息

Department of Neurosurgery, Klinikum Grosshadern, Munich, Germany.

出版信息

World Neurosurg. 2010 Oct-Nov;74(4-5):513-6. doi: 10.1016/j.wneu.2010.06.020. Epub 2011 Jan 12.

Abstract

BACKGROUND

Most primary lymphomas of the central nervous system (CNS) are of B-cell origin and are found intra-axially, with a few reported cases of skull base tumors involving the upper clivus or sellar region or both. In this case, a tumor resembling a clivus meningioma without osseous involvement was surgically removed and turned out to be a primary T-cell lymphoma.

CASE REPORT

A 60-year-old woman presented with slight right-sided abducens nerve palsy. Cranial imaging revealed an extra-axial mass at the caudal clivus resembling a meningioma. The tumor was removed surgically; smear preparations obtained intraoperatively were inconclusive presumably because of preoperative steroid treatment. The final diagnosis was peripheral T-cell lymphoma, not otherwise unspecified. The patient developed a secondary meningiosis supposedly caused by surgery.

CONCLUSIONS

Although a very rare entity among primary T-cell lymphomas of the CNS, these tumors also can occur as skull base lesions without involvement of the bone. Preoperative steroid medication may complicate intraoperative histologic assessment and lead to inadequate treatment of these tumors.

摘要

背景

大多数中枢神经系统(CNS)原发性淋巴瘤为 B 细胞来源,位于轴内,少数颅底肿瘤报告病例涉及上斜坡或鞍区或两者均有累及。在本例中,手术切除了一个类似于无骨累及斜坡脑膜瘤的肿瘤,结果证实为原发性 T 细胞淋巴瘤。

病例报告

一名 60 岁女性出现轻微右侧展神经麻痹。颅部成像显示颅底斜坡的颅外肿块类似于脑膜瘤。肿瘤被手术切除;术中获得的涂片准备结果不确定,可能是由于术前类固醇治疗。最终诊断为外周 T 细胞淋巴瘤,非特指型。患者发生继发性脑膜炎,推测由手术引起。

结论

尽管中枢神经系统原发性 T 细胞淋巴瘤非常罕见,但这些肿瘤也可以作为颅底病变而不涉及骨骼。术前类固醇药物可能会使术中组织学评估复杂化,并导致这些肿瘤的治疗不足。

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