一种评估妊娠期间宫颈变化的新光学方法，并用于评估孕激素对足月和早产的影响。
A novel optical method to assess cervical changes during pregnancy and use to evaluate the effects of progestins on term and preterm labor.
机构信息
Department of Obstetrics and Gynecology of the St. Joseph's Hospital and Medical Center, Phoenix, AZ 85004, USA.
出版信息
Am J Obstet Gynecol. 2011 Jul;205(1):82.e15-20. doi: 10.1016/j.ajog.2011.02.048. Epub 2011 Feb 23.
Abstract
OBJECTIVE
The purpose of this study was to determine whether optical methods can estimate cervix function during pregnancy and whether progestins modify this process.
STUDY DESIGN
Photos of the external cervix of timed-pregnant rats were taken every other day from day 13 until postpartum day 5 after daily treatments with vehicle (controls) or progestin treatments (progesterone, subcutaneously or vaginally; 17-alpha-hydroxyprogesterone caproate [17P] and RU-486 subcutaneously, once on day 16). The surface area of the cervix was estimated from photos.
RESULTS
The surface area of cervix increases throughout pregnancy and reverses after delivery in controls. In the progesterone subcutaneously or 17P subcutaneously groups, increases in surface area are lower (17P group until day 19 only; P < .05). Vaginal progesterone does not prevent surface area increases. Only the progesterone subcutaneously blocked delivery. RU-486 increases the surface area of the cervix (P < .05) during preterm delivery.
CONCLUSION
An optical method is useful for quantitative assessment of the cervix and evaluation of agents that modify cervical function.
摘要
目的
本研究旨在确定光学方法是否可用于评估妊娠期间子宫颈功能，以及孕激素是否会改变这一过程。
研究设计
从妊娠第 13 天开始，每隔一天对定时妊娠大鼠的子宫颈外部拍照，直至产后第 5 天。每日给予载体（对照组）或孕激素治疗（孕酮，皮下或阴道；17-α-羟孕酮己酸酯[17P]和 RU-486，皮下，仅在第 16 天一次）。从照片中估计子宫颈的表面积。
结果
在对照组中，子宫颈的表面积在整个妊娠期间增加，并在分娩后恢复。在皮下注射孕酮或 17P 组中，表面积的增加较低（17P 组仅在第 19 天；P<0.05）。阴道用孕酮不能防止表面积的增加。只有皮下注射孕酮阻止了分娩。RU-486 在早产期间增加子宫颈的表面积（P<0.05）。
结论
光学方法可用于定量评估子宫颈，并评估改变子宫颈功能的药物。
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2
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