Y 染色体单倍群 O 的更新树及突变 P164 和 PK4 的修正系统发育位置。
An updated tree of Y-chromosome Haplogroup O and revised phylogenetic positions of mutations P164 and PK4.
机构信息
State Key Laboratory of Genetic Engineering and Ministry of Education, Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
出版信息
Eur J Hum Genet. 2011 Sep;19(9):1013-5. doi: 10.1038/ejhg.2011.64. Epub 2011 Apr 20.
Y-chromosome Haplogroup O is the dominant lineage of East Asians, comprising more than a quarter of all males on the world; however, its internal phylogeny remains insufficiently investigated. In this study, we determined the phylogenetic position of recently defined markers (L127, KL1, KL2, P164, and PK4) in the background of Haplogroup O. In the revised tree, subgroup O3a-M324 is divided into two main subclades, O3a1-L127 and O3a2-P201, covering about 20 and 35% of Han Chinese people, respectively. The marker P164 is corrected from a downstream site of M7 to upstream of M134 and parallel to M7 and M159. The marker PK4 is also relocated from downstream of M88 to upstream of M95, separating the former O2(*) into two parts. This revision evidently improved the resolving power of Y-chromosome phylogeny in East Asia.
Y 染色体单倍群 O 是东亚人的主要谱系，占世界上所有男性的四分之一以上；然而，其内部系统发育仍未得到充分研究。在这项研究中，我们确定了最近定义的标记（L127、KL1、KL2、P164 和 PK4）在 O 单倍群背景下的系统发育位置。在修订后的树中，O3a-M324 亚群分为两个主要的分支，O3a1-L127 和 O3a2-P201，分别覆盖了约 20%和 35%的汉族人。标记 P164 从 M7 的下游位置修正到 M134 的上游，与 M7 和 M159 平行。标记 PK4 也从 M88 的下游位置重新定位到 M95 的上游，将原来的 O2(*) 分为两部分。这一修正明显提高了东亚地区 Y 染色体系统发育的分辨率。
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