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[采用分层皮片进行自体皮肤移植治疗坏疽性脓皮病]

[Autodermoplasty with split skin grafts in treatment of pyoderma gangrenosum].

作者信息

Andreev D Iu

出版信息

Vestn Khir Im I I Grek. 2011;170(1):72-5.

Abstract

Pyoderma gangrenosum (PG) is a rare infectious disease which usually shows itself as painful ulcers on the lower leg. At the present time the autoimmune nature of the disease seems to be most probable. PG is characterized by a phenomenon of pathergy--actuation of the inflammatory process and appearance of ulcers in traumas of the skin. So autodermoplasty of the ulcers in case of PG was "under a ban". In the recent time there appeared publications justifying using methods under conditions of systemic immunosuppressive therapy. Unfortunately the latter is often associated with a great number of side effects which sometimes can result in death.

摘要

坏疽性脓皮病(PG)是一种罕见的感染性疾病,通常表现为小腿上的疼痛性溃疡。目前,该疾病的自身免疫性质似乎最为可能。PG的特征是同形反应现象——皮肤创伤处炎症过程的激发和溃疡的出现。因此,PG患者溃疡的自体皮肤移植术曾被“禁止”。最近出现了一些出版物,证明在全身免疫抑制治疗的条件下使用相关方法是合理的。不幸的是,后者常常伴有大量副作用,有时甚至会导致死亡。

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