帕金森病中文撤药问卷9症状版的验证研究。
A validation study of the Chinese wearing off questionnaire 9-symptom for Parkinson's disease.
作者信息
Chan A, Cheung Y F, Yeung M Au, Yeung J, Chung T H, Tsang K L, Chan J, Lau C, Kwan P, Kuo Sheng-Han, Mok V
机构信息
Department of Medicine and Therapeutics, Prince of Wales Hospital, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China.
出版信息
Clin Neurol Neurosurg. 2011 Sep;113(7):538-40. doi: 10.1016/j.clineuro.2011.03.007. Epub 2011 Apr 20.
OBJECTIVE
Development of wearing off (WO) often goes unnoticed for both patients with Parkinson's disease (PD) and physicians due to the complexity of this phenomenon. A brief 9-symptom WO questionnaire (WOQ-9) was recently found to be highly sensitive in its detection. We aimed to validate a Chinese version WOQ-9 (CWOQ-9) among Chinese patients with PD.
METHODS
We recruited 101 literate Chinese PD patients among 4 different neurology or movement disorders clinics in Hong Kong to participate in this study by completing the CWOQ-9. Clinical judgment by the specialists was considered the gold standard for diagnosing WO.
RESULTS
The mean age (±SD) of the patients was 61 (±9) years and 35 (34.7%) of them were female. The disease duration was 7.4 (±5.4) years and 69 (68.3%) of them were diagnosed clinically to have WO by the specialists. The positive and negative predictive values, sensitivity and specificity of CWOQ-9 were 86%, 71%, 87%, and 69% respectively. The area under curve (AUC) was 0.78 (p<0.001).
CONCLUSION
This simple patient questionnaire is a valid tool for the detection of WO among Chinese PD patients.
目的
由于帕金森病（PD）患者症状波动现象复杂，患者和医生常常未能察觉其出现。最近发现一份包含9个症状的简短症状波动问卷（WOQ - 9）对症状波动的检测具有高度敏感性。我们旨在对中国PD患者群体验证中文版WOQ - 9（CWOQ - 9）。
方法
我们在香港4家不同的神经内科或运动障碍诊所招募了101名识字的中国PD患者，通过填写CWOQ - 9参与本研究。专家的临床判断被视为诊断症状波动的金标准。
结果
患者的平均年龄（±标准差）为61（±9）岁，其中35名（34.7%）为女性。病程为7.4（±5.4）年，其中69名（68.3%）经专家临床诊断存在症状波动。CWOQ - 9的阳性预测值、阴性预测值、敏感性和特异性分别为86%、71%、87%和69%。曲线下面积（AUC）为0.78（p<0.001）。
结论
这份简单的患者问卷是检测中国PD患者症状波动的有效工具。
Zotero 插件