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2-(1H-吲哚-3-甲酰胺基)乙酸甲酯

Methyl 2-(1H-indole-3-carboxamido)-acetate.

作者信息

Hu Fang, Zheng Le, Zeng Xiang Chao, Li Kai Ping

机构信息

Department of Chemistry, Jinan University, Guangzhou, Guangdong 510632, People's Republic of China.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2011 Feb 26;67(Pt 3):o742. doi: 10.1107/S1600536811006660.

Abstract

The title compound, C(12)H(12)N(2)O(3), was synthesized by condensation of methyl amino-acetate with 3-trichloro-acetyl-indole. In the crystal, inter-molecular N-H⋯O hydrogen bonds link the mol-ecules into chains parallel to the b axis. The chains are further connected into a three-dimensional network by N-H⋯O hydrogen bonds involving the indole N atom. In the molecule, the indole skeleton is nearly planar [maximum deviation = 0.012 (1) Å] and the mean plane of the amido group is twisted from the mean plane of indole ring by 17.2 (1)°.

摘要

标题化合物C(12)H(12)N(2)O(3)是通过氨基乙酸甲酯与3-三氯乙酰基吲哚缩合合成的。在晶体中,分子间的N-H⋯O氢键将分子连接成平行于b轴的链。这些链通过涉及吲哚N原子的N-H⋯O氢键进一步连接成三维网络。在分子中,吲哚骨架几乎是平面的[最大偏差 = 0.012 (1) Å],酰胺基的平均平面与吲哚环的平均平面扭转了17.2 (1)°。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d712/3052031/d985c5c41cb9/e-67-0o742-fig1.jpg

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