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2-[4-(2-甲氧基苯基)哌嗪-1-基]-N-(吡啶-2-基)乙酰胺

2-[4-(2-Meth-oxy-phen-yl)piperazin-1-yl]-N-(pyridin-2-yl)acetamide.

作者信息

Lu Chunxiong, Jiang Quanfu

机构信息

Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, People's Republic of China.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2010 Dec 24;67(Pt 1):o223. doi: 10.1107/S1600536810053067.

Abstract

In the title compound, C(18)H(22)N(4)O(2), the piperizine ring adopts a chair conformation and the dihedral angle between the pyridine and benzene rings is 67.6 (9)°. The conformations of the attachment of the anisole and N-ethyl-pyridin-2-amine groups to the piperazine ring are (+)anti-periplanar. Intra-molecular C-H⋯O and N-H⋯N inter-actions occur. In the crystal, inter-molecular C-H⋯N hydrogen bonds are present. There are two crystallographically independent but identical mol-ecules per asymmetric unit.

摘要

在标题化合物C(18)H(22)N(4)O(2)中,哌嗪环呈椅式构象,吡啶环与苯环之间的二面角为67.6 (9)°。苯甲醚和N-乙基吡啶-2-胺基团与哌嗪环相连的构象为(+)反式共平面。分子内存在C-H⋯O和N-H⋯N相互作用。在晶体中,存在分子间C-H⋯N氢键。每个不对称单元中有两个晶体学上独立但相同的分子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57d7/3050313/e51a272903bf/e-67-0o223-fig1.jpg

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