Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan.
Am J Hypertens. 2011 Aug;24(8):924-9. doi: 10.1038/ajh.2011.74. Epub 2011 Apr 28.
We previously showed that the C→T polymorphism (rs6929846) in butyrophilin, subfamily 2, member A1 gene (BTN2A1) was associated with myocardial infarction in Japanese individuals. Given that hypertension is a major risk factor for myocardial infarction, the association of rs6929846 of BTN2A1 with myocardial infarction might be attributable, at least in part, to its effect on susceptibility to hypertension. We have thus examined the relation of rs6929846 of BTN2A1 to hypertension in Japanese individuals.
A total of 8,567 Japanese individuals from two independent subject panels were examined: Subject panels A and B comprised 2,317 hypertensive individuals and 1,933 controls, and 2,911 hypertensive individuals and 1,406 controls, respectively. The genotype of rs6929846 was determined by a method that combines the PCR and sequence-specific oligonucleotide probes with suspension array technology.
Multivariable logistic regression analysis with adjustment for covariates revealed that rs6929846 of BTN2A1 was significantly associated with hypertension in subject panel A (P = 2.6 × 10(-6); odds ratio, 1.69) and in subject panel B (P = 0.0284; odds ratio, 1.24), with the T allele representing a risk factor for hypertension. The rs6929846 was associated with systolic blood pressure (BP) in subject panels A (P = 0.0063) and B (P = 0.0115) and with diastolic BP in subject panel B (P = 0.0323), with the T allele being related to high BP.
BTN2A1 may be a susceptibility gene for hypertension in Japanese individuals. Determination of genotype for this polymorphism may prove informative for assessment of the genetic risk for hypertension.
我们之前的研究表明，BTN2A1 基因（butyrophilin，subfamily 2，member A1）中的 C→T 多态性（rs6929846）与日本人的心肌梗死有关。鉴于高血压是心肌梗死的主要危险因素，BTN2A1 的 rs6929846 与心肌梗死的关联可能至少部分归因于其对高血压易感性的影响。因此，我们检查了 BTN2A1 的 rs6929846 与日本人高血压之间的关系。
我们共检查了来自两个独立的研究对象小组的 8567 名日本个体：研究对象 A 组和 B 组分别包含 2317 名高血压个体和 1933 名对照个体，以及 2911 名高血压个体和 1406 名对照个体。rs6929846 的基因型通过结合 PCR 和序列特异性寡核苷酸探针与悬浮阵列技术的方法来确定。
多变量逻辑回归分析显示，BTN2A1 的 rs6929846 与研究对象 A 组（P = 2.6×10(-6)；比值比，1.69）和研究对象 B 组（P = 0.0284；比值比，1.24）的高血压显著相关，T 等位基因代表高血压的危险因素。rs6929846 与研究对象 A 组（P = 0.0063）和 B 组（P = 0.0115）的收缩压（BP）以及研究对象 B 组（P = 0.0323）的舒张压有关，T 等位基因与高血压有关。
BTN2A1 可能是日本人高血压的易感基因。该多态性的基因型测定可能对评估高血压的遗传风险具有信息意义。
