神经元活动驱动突触成熟过程中前后突触功能的匹配。
Neuronal activity drives matching of pre- and postsynaptic function during synapse maturation.
机构信息
MRC Centre for Developmental Neurobiology, King's College London, London, UK.
出版信息
Nat Neurosci. 2011 Jun;14(6):688-90. doi: 10.1038/nn.2826. Epub 2011 May 1.
DOI:10.1038/nn.2826
PMID:21532580
Abstract
The structure and function of presynaptic and postsynaptic compartments varies markedly in neurons, but little is known about how they are functionally arranged with respect to each other. In rat hippocampal neurons, we found that, although they are structurally correlated from the early moments of formation, synapses only gradually become functionally matched and that this process is dependent on ongoing electrical activity.
摘要
突触前和突触后隔室的结构和功能在神经元中差异显著，但对于它们彼此之间的功能排列方式知之甚少。在大鼠海马神经元中，我们发现，尽管它们在形成的早期就具有结构相关性，但突触只是逐渐变得功能匹配，而且这个过程依赖于持续的电活动。
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