Modrau B, Sørensen L, Bartholdy N J, von Weitzel-Mudersbach P, Andersen G, Rasmussen P V
Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.
Case Rep Neurol. 2011 Apr 12;3(1):91-6. doi: 10.1159/000327554.
Thrombolytic therapy is not recommended for acute ischemic stroke (AIS) in patients under the age of 18 and published experience is limited. In this case report, we describe two children treated with systemic thrombolytic therapy. One child received additional mechanical revascularization and achieved a good clinical outcome. The differences in the fibrinolytic system and the different etiology of AIS in childhood may limit a simple extrapolation of the adult guidelines for systemic thrombolytic therapy. Acute multimodal imaging to clarify the etiology of AIS might help to select the most appropriate treatment modality.
不建议对18岁以下的急性缺血性卒中（AIS）患者进行溶栓治疗，且已发表的相关经验有限。在本病例报告中，我们描述了两名接受全身溶栓治疗的儿童。其中一名儿童接受了额外的机械血管重建并取得了良好的临床结果。儿童期纤溶系统的差异以及AIS的不同病因可能会限制简单地外推成人全身溶栓治疗指南。采用急性多模态成像来明确AIS的病因可能有助于选择最合适的治疗方式。
