2型糖尿病患者心血管自主神经病变及QT间期延长与心血管发病率和死亡率的关联

[Association of cardiovascular autonomic neuropathy and prolonged QT interval with cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus].

作者信息

Ticse Aguirre Ray, Villena Jaime E

机构信息

Departamento de Medicina, Hospital Nacional Cayetano Heredia.

出版信息

Rev Peru Med Exp Salud Publica. 2011 Mar;28(1):83-6. doi: 10.1590/s1726-46342011000100013.

DOI:10.1590/s1726-46342011000100013

PMID:21537774

Abstract

In order to evaluate the relationship between cardiovascular autonomic neuropathy and corrected QT interval (QTc) with cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus, we followed up for 5 years 67 patients attending the outpatient Endocrinology Service. 82% completed follow-up and cardiovascular events occurred in 16 patients. We found that long QTc interval was the only variable significantly associated with cardiovascular morbidity and mortality in the multiple logistic regression analysis (RR: 13.56, 95% CI: 2.01-91.36) (p = 0.0074).

摘要

为了评估2型糖尿病患者心血管自主神经病变与校正QT间期（QTc）和心血管发病率及死亡率之间的关系，我们对67名内分泌科门诊患者进行了5年的随访。82%的患者完成了随访，16名患者发生了心血管事件。我们发现，在多因素logistic回归分析中，长QTc间期是与心血管发病率和死亡率显著相关的唯一变量（相对风险：13.56，95%置信区间：2.01 - 91.36）（p = 0.0074）。