幽门螺杆菌铁摄取调节因子（Fur）对氯化钠胁迫下的生长是必不可少的。
The Helicobacter pylori Ferric Uptake Regulator (Fur) is essential for growth under sodium chloride stress.
机构信息
Department of Microbiology and Immunology, Uniformed Services University of Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA.
出版信息
J Microbiol. 2011 Apr;49(2):294-8. doi: 10.1007/s12275-011-0396-7. Epub 2011 May 3.
Abstract
Epidemiological data and animal models indicate that Helicobacter pylori and dietary NaCl have a synergistic ill effect on gastric maladies. Here we show that the Ferric Uptake Regulator (Fur), which is a crucial regulatory factor required for H. pylori colonization, is essential for growth in the presence of high NaCl concentrations. Moreover, we demonstrate that the transcriptional response induced by sodium chloride stress exhibits similarities to that seen under iron depletion.
摘要
流行病学数据和动物模型表明，幽门螺杆菌和膳食氯化钠对胃部疾病有协同的不良影响。在这里，我们表明，铁摄取调节剂（Fur）是幽门螺杆菌定植所必需的关键调节因子，对于高氯化钠浓度下的生长是必不可少的。此外，我们证明了氯化钠胁迫引起的转录反应与铁耗竭时观察到的反应相似。
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