人嗜T淋巴细胞病毒1型Tax蛋白的翻译后修饰在核因子κB激活中的作用
Role of post-translational modifications of HTLV-1 Tax in NF-κB activation.
作者信息
Shembade Noula, Harhaj Edward W
机构信息
Noula Shembade, Edward W Harhaj, Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL 33136, United States.
出版信息
World J Biol Chem. 2010 Jan 26;1(1):13-20. doi: 10.4331/wjbc.v1.i1.13.
Abstract
Human T-cell leukemia virus type 1 (HTLV-1), the first human retrovirus discovered, is the etiological agent of adult-T-cell leukemia/lymphoma. The HTLV-1 encoded Tax protein is a potent oncoprotein that deregulates gene expression by constitutively activating nuclear factor-κB (NF-κB). Tax activation of NF-κB is critical for the immortalization and survival of HTLV-1-infected T cells. In this review, we summarize the present knowledge on mechanisms underlying Tax-mediated NF-κB activation, with an emphasis on post-translational modifications of Tax.
摘要
人类T细胞白血病病毒1型（HTLV-1）是发现的第一种人类逆转录病毒，是成人T细胞白血病/淋巴瘤的病原体。HTLV-1编码的Tax蛋白是一种有效的癌蛋白，通过持续激活核因子κB（NF-κB）来失调基因表达。Tax对NF-κB的激活对于HTLV-1感染的T细胞的永生化和存活至关重要。在本综述中，我们总结了目前关于Tax介导的NF-κB激活机制的知识，重点是Tax的翻译后修饰。
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