Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical Center, 109 Zina Pitcher, 2053 BSRB, Ann Arbor, MI 48109-2200, USA.
Pediatr Nephrol. 2011 Sep;26(9):1559-65. doi: 10.1007/s00467-011-1902-1. Epub 2011 May 8.
The adult mammalian kidney is generated by the differentiation and integration of several distinct cell types, including the nephrogenic mesenchyme, ureteric epithelium, stromal and endothelial cells. How and where these cell types are generated and what signals lead to their differentiation and integration into a functional organ system is a main focus of current studies. Herein, we review the formation of distinct cell types within the adult mammalian kidney; what is understood regarding their origin and the signaling pathways that lead to their formation and integration; morphogenetic changes the metanephric kidney undergoes during development; and what is known regarding the role of Hox genes in these processes.
成年哺乳动物的肾脏是由几种不同类型的细胞分化和整合而成的，包括肾间充质、输尿管上皮、基质和内皮细胞。这些细胞类型是如何以及在哪里产生的，以及什么信号导致它们分化和整合为一个功能器官系统，是当前研究的主要焦点。在此，我们回顾了成年哺乳动物肾脏内不同细胞类型的形成；了解它们的起源以及导致其形成和整合的信号通路；后肾发生过程中肾脏经历的形态发生变化；以及 Hox 基因在这些过程中的作用。
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