X 连锁 GPR50 基因内含子 rs2072621 多态性与季节性情感障碍的关联。

Association of the intronic rs2072621 polymorphism of the X-linked GPR50 gene with affective disorder with seasonal pattern.

机构信息

Inserm U, laboratoire de physiopathologie des maladies psychiatriques, faculté de médecine Paris Descartes, université Paris Descartes, France.

出版信息

Eur Psychiatry. 2012 Jul;27(5):369-71. doi: 10.1016/j.eurpsy.2011.02.011. Epub 2011 May 11.

DOI:10.1016/j.eurpsy.2011.02.011

PMID:21565467

Abstract

This case-control study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 (an orphan member of the G protein-coupled melatonin receptor subfamily) in females. This may represent a gender-specific risk factor and a molecular link between melatonin and SAD.

摘要

本病例对照研究发现，女性季节性情感障碍（SAD）与编码 G 蛋白偶联褪黑素受体亚家族孤儿成员 GPR50 的基因的单核苷酸多态性（内含子 rs2072621）之间存在关联。这可能代表了一种性别特异性的风险因素，以及褪黑素和 SAD 之间的分子联系。