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部分泪小点阻塞治疗干燥综合征相关干眼的两年疗效观察。

Two-year outcome of partial lacrimal punctal occlusion in the management of dry eye related to Sjögren syndrome.

机构信息

Department of Ophthalmology, Hospital das Clínicas of University of São Paulo, Brazil.

出版信息

Curr Eye Res. 2011 Jun;36(6):507-12. doi: 10.3109/02713683.2011.569870.

Abstract

PURPOSE

To analyze the influence of thermal partial punctal occlusion on the ocular surface of dry eye related to Sjögren syndrome.

MATERIAL AND METHODS

Thirty-seven eyes of 19 patients (3 male and 16 female; 49.11 ± 14.33 years old) with keratoconjunctivitis sicca were enrolled in this study. Superior and inferior partial occlusion were performed in both eyes under topical anesthesia using thermal cautery with a sterile tip to obtain lacrimal punctum smaller than 0.5 mm. Schirmer I, break-up-time, diameter of lacrimal puncta, corneal fluorescein, and rose Bengal staining scores were analyzed before and after 24 weeks and after 24 months of the procedure. All measurements were performed under controlled climate.

RESULTS

The average lacrimal punctum diameter before the procedure was 0.65 ± 0.134 mm. All lacrimal puncta were successfully reduced to less than 0.5 mm after 4 weeks of the procedure. The average Schirmer I test values improved statistically after 24 weeks and maintained stable after 24 months. Average break-up-time, rose Bengal, and fluorescein staining score values improved statistically after 24 weeks and improved even more after 24 months. Average Schirmer I test, break-up-time, rose Bengal, and fluorescein staining scores showed significant improvement (p < 0.0001) after 24 months of partial thermal punctal occlusion.

CONCLUSION

Our study showed that reducing the punctum diameter to 0.5 mm can improve vital staining scores, break-up-time, and Schirmer I test in dry eye related to Sjögren syndrome.

摘要

目的

分析热部分泪点封闭对干燥性角结膜炎相关干燥综合征患者眼表的影响。

材料与方法

本研究纳入 19 例(3 名男性,16 名女性;年龄 49.11±14.33 岁)共 37 只眼的患者,这些患者均患有角结膜干燥症。在局部麻醉下使用无菌尖端的热烧灼对双眼进行上、下部分泪点封闭,以获得小于 0.5mm 的泪小点。在 24 周和 24 个月后分别分析泪液分泌试验(Schirmer I 试验)、泪膜破裂时间(BUT)、泪点直径、角膜荧光素和丽丝胺绿染色评分。所有测量均在受控环境下进行。

结果

术前平均泪点直径为 0.65±0.134mm。所有泪点在术后 4 周均成功缩小至小于 0.5mm。术后 24 周 Schirmer I 试验值统计学上有改善,24 个月后保持稳定。术后 24 周平均 BUT、丽丝胺绿和荧光素染色评分统计学上有改善,24 个月后改善更明显。术后 24 个月,Schirmer I 试验、BUT、丽丝胺绿和荧光素染色评分均有显著改善(p<0.0001)。

结论

本研究表明,将泪点直径缩小至 0.5mm 可改善干燥性角结膜炎相关干燥综合征患者的荧光素染色评分、BUT 和 Schirmer I 试验。

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