果蝇残翅基因和粗糙基因与Notch基因座的相互作用。
Interactions of vestigial and scabrous with the Notch locus of Drosophila melanogaster.
作者信息
Rabinow L, Birchler J A
机构信息
Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138.
出版信息
Genetics. 1990 May;125(1):41-50. doi: 10.1093/genetics/125.1.41.
Abstract
Interactions are described between the Notch locus of Drosophila melanogaster, and two other loci, scabrous and vestigial, which respectively affect the eyes and wings. The Notch locus is responsible for mediating decisions of cell fate throughout development in many different tissues. Mutations and duplications of vestigial and scabrous alter the severity of phenotypes associated with Notch mutations and duplications in a manner that is essentially tissue- and allele-specific. These interactions indicate that the products of vestigial and scabrous act in conjunction with Notch to stimulate the differentiation of specific cell types.
摘要
本文描述了黑腹果蝇Notch基因座与另外两个基因座（粗糙基因和残翅基因）之间的相互作用，这两个基因座分别影响眼睛和翅膀。Notch基因座负责在许多不同组织的整个发育过程中介导细胞命运的决定。残翅基因和粗糙基因的突变及重复以一种基本依赖于组织和等位基因特异性的方式改变了与Notch突变及重复相关的表型严重程度。这些相互作用表明，残翅基因和粗糙基因的产物与Notch协同作用，刺激特定细胞类型的分化。
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