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[永久性起搏器患者的心房颤动患病率及口服抗凝治疗]

[Atrial fibrillation prevalence and treatment with oral anticoagulation in patients with permanent pacemakers].

作者信息

Arce Mauricio, Femenía Francisco, Palazzolo Jorge, Trucco Emilce, Rodriguez Carlos, Baranchuk Adrián

机构信息

Unidad de Arritmias, Departamento de Cardiología, Hospital Español Mendoza, Argentina.

出版信息

Invest Clin. 2011 Mar;52(1):58-68.

Abstract

Atrial Fibrillation (AF) is the most important risk factor for stroke and thromboembolic events (TE). The aims of this study were to determine the prevalence of AF among patients with permanent pacemakers (PPM), the percentage of anticoagulated patients and the prevalence on TE in this population. The secondary purpose was to determine the "level of knowledge" about indications of anticoagulation for AF patients. This was a descriptive and retrospective study on a consecutive series of patients referred for PPM implantation. Cardiovascular risk factors, indications for pacing, prior history of AF, TE and anticoagulation indication were analyzed. In order to determine possible causes for not indicating anticoagulation, an electronic survey was sent to all doctors that usually refer patients for PPM implant and follow-up to our clinic. Among 934 patients, 26% (244) presented AF of which 34% were anticoagulated. 77.3% presented a CHADS2 score of > or = 2 while only 2% had absolute contraindication for anticoagulation. The prevalence of TE was 9%. More than 60% of the doctors answered the survey. More than 40% acknowledged the CHADS, score but only 33% were able to recognize all variables included in the score and 23% were able to determine when to indicate anticoagulation properly. A low anticoagulation rate was detected among patients with AF and PPM with a high prevalence of TE and stroke. An extremely low adherence to international guidelines was detected among doctors that usually deal with this sort of patients.

摘要

心房颤动(AF)是中风和血栓栓塞事件(TE)最重要的危险因素。本研究的目的是确定永久性起搏器(PPM)患者中AF的患病率、接受抗凝治疗患者的百分比以及该人群中TE的患病率。次要目的是确定AF患者抗凝治疗适应证的“知识水平”。这是一项对连续一系列因植入PPM而转诊的患者进行的描述性回顾性研究。分析了心血管危险因素、起搏适应证、AF既往史、TE和抗凝治疗适应证。为了确定未给予抗凝治疗的可能原因,向所有通常将患者转诊至我们诊所进行PPM植入和随访的医生发送了电子调查问卷。在934例患者中,26%(244例)存在AF,其中34%接受了抗凝治疗。77.3%的患者CHADS2评分≥2,而只有2%的患者有抗凝治疗的绝对禁忌证。TE的患病率为9%。超过60%的医生回复了调查问卷。超过40%的医生认可CHADS2评分,但只有33%的医生能够识别该评分中包含的所有变量,23%的医生能够正确确定何时给予抗凝治疗。在AF和PPM患者中检测到抗凝率较低,TE和中风的患病率较高。在通常处理这类患者的医生中,检测到对国际指南的依从性极低。

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