Center for Reproductive Medicine, Obstetrics and Gynecology, and the Women's Health Institute, Cleveland Clinic, Cleveland, Ohio, USA.
J Minim Invasive Gynecol. 2011 Jul-Aug;18(4):419-27. doi: 10.1016/j.jmig.2011.03.009. Epub 2011 May 26.
Endometriosis is defined as the presence of endometrial tissue outside the uterine cavity and is considered a benign gynecologic condition; however, in some cases, it may be aggressive. The pathogenesis of endometriosis is complex and multifactorial. Despite being one of the most widely studied gynecologic diseases, its pathogenesis remains uncertain. The intrinsic endometrial abnormalities thought to be associated with endometriosis include abnormal expression of genes, modification of endometrial response to hormones such as progesterone; increased nerve density, and oxidative stress. Evaluation of the endometrium in patients with endometriosis is an important line of investigation in the pathophysiology of the disease. It has been suggested that investigation of eutopic endometrium may help to achieve this goal. Presented herein is a literature review and a comprehensive evaluation of the role of eutopic endometrium in pelvic endometriosis. Clinical correlations of the disease are highlighted, with the objective of understanding the role of eutopic endometrium in endometriosis.
子宫内膜异位症是指子宫内膜组织出现在子宫腔外，被认为是一种良性妇科疾病；然而，在某些情况下，它可能具有侵袭性。子宫内膜异位症的发病机制复杂且多因素。尽管它是研究最广泛的妇科疾病之一，但发病机制仍不确定。与子宫内膜异位症相关的内在子宫内膜异常包括基因表达异常、对孕激素等激素的子宫内膜反应改变；神经密度增加和氧化应激。评估子宫内膜异位症患者的子宫内膜是研究疾病病理生理学的重要线索。有人认为，研究在位子宫内膜可能有助于实现这一目标。本文对盆腔子宫内膜异位症中在位子宫内膜的作用进行了文献复习和全面评估。突出了疾病的临床相关性，目的是了解在位子宫内膜在子宫内膜异位症中的作用。
