Babala P, Bíró C, Klacko M, Miklos P, Ondrus D
Department of Gynecologic Oncology, St. Elizabeth Cancer Institute, Bratislava, Slovak Republic.
Klin Onkol. 2011;24(2):133-6.
Angiomyofibroblastoma (AMFB) is a rare histopathologic finding of the female lower genital tract. This tumor belongs to the group of mesenchymal tumors. Mesenchymal neoplasms of the modified genital skin and mucosa are uncommon. The majority of these lesions are seen in females and, collectively, they form a family of vulvovaginal soft tissue tumors. This family includes fibroepithelial stromal polyps, angiomyofibroblastoma, cellular angiofibroma, aggressive angiomyxoma, vaginocervical myofibroblastoma, vulvar leiomyomatosis, and other smooth muscle tumors. Angiomyofibroblastoma is a benign tumor, histologically very similar to pelvic aggressive angiomyxoma (AMM), a distinctive, locally infiltrative but non-metastasizing mesenchymal neoplasm with a tendency to occur in the female pelvic and perineal regions.
44 years old woman with angiomyofibroblastoma of cervix uteri.
A recognition of this entity is important to avoid misdiagnosis of other angiomyxoid neoplasms. Furthermore, unlike other, more aggressive, mesenchymal tumors of the lower genital tract, AMFB shows benign behaviour.
血管肌纤维母细胞瘤(AMFB)是女性下生殖道一种罕见的组织病理学表现。该肿瘤属于间叶组织肿瘤。改良的生殖器皮肤和黏膜的间叶组织肿瘤并不常见。这些病变大多数见于女性,它们共同构成了一组外阴阴道软组织肿瘤。这组肿瘤包括纤维上皮性间质息肉、血管肌纤维母细胞瘤、细胞性血管纤维瘤、侵袭性血管黏液瘤、阴道宫颈肌纤维母细胞瘤、外阴平滑肌瘤病以及其他平滑肌肿瘤。血管肌纤维母细胞瘤是一种良性肿瘤,在组织学上与盆腔侵袭性血管黏液瘤(AMM)非常相似,后者是一种独特的、局部浸润但不转移的间叶组织肿瘤,倾向于发生在女性盆腔和会阴区域。
一名44岁患有子宫颈血管肌纤维母细胞瘤的女性。
认识这一实体对于避免误诊其他血管黏液样肿瘤很重要。此外,与下生殖道其他更具侵袭性的间叶组织肿瘤不同,AMFB表现为良性行为。