Cheng Shaomin, Zhao Haimei, Zuo Zhiqin, Wang Yanhui, Wang Yuesheng, Liu Duanyong
Jiangxi University of Traditional Chinese Medicine, College of Basic Medicine, Nanchang 330006, China.
Zhongguo Zhong Yao Za Zhi. 2011 Mar;36(5):633-5.
To observe effect of oral scorpio and scolopendra powder on T-cell subsets in peripheral blood and intestine from rats with collagen induced arthritis (CIA).
60 rats were randomly divided into 6 groups: normal control group, model control group, low-dose scorpio and scolopendra group, middle-dose scorpio and scolopendra group, high-dose scorpio and scolopendra group, and type II collagen group. Rat's rheumatoid arthritis was induced by collagen II (C II). Level of T-cell subsets from peripheral blood and intestine was measured by flow cytometry.
CD4+ T cellular level was obviously increased (P < 0.05 or P < 0.01) or kept increased tendency in peripheral blood and intestine from the model group compared with that of the normal group, while the ratio of CD4+/CD8+ in intestine was obviously descent but the contrary in peripheral blood (P < 0.05 or P < 0.01). CD4+, CD8+ T cellular level in intestine were obviously descent and the ratio of CD4+ /CD8+ increased in all treated groups when compared with in the model group (P < 0.05 or P < 0.01). However, CD4+ T cellular level and the ratio of CD4+/CD8+ in peripheral blood were remarkablely decreased.
The mechanism that scorpio and scolopendra could treat rat's rheumatoid arthritis may be regulating balance of T-lymphocyte subsets in peripheral blood and intestine.
观察口服全蝎蜈蚣粉对胶原诱导性关节炎（CIA）大鼠外周血及肠道T细胞亚群的影响。
将60只大鼠随机分为6组：正常对照组、模型对照组、低剂量全蝎蜈蚣组、中剂量全蝎蜈蚣组、高剂量全蝎蜈蚣组和Ⅱ型胶原组。用Ⅱ型胶原（CⅡ）诱导大鼠类风湿性关节炎。采用流式细胞术检测外周血及肠道T细胞亚群水平。
与正常组相比，模型组外周血及肠道中CD4+ T细胞水平明显升高（P<0.05或P<0.01）或呈升高趋势，而肠道中CD4+/CD8+比值明显下降，外周血中则相反（P<0.05或P<0.01）。与模型组相比，各治疗组肠道中CD4+、CD8+ T细胞水平明显下降，CD4+/CD8+比值升高（P<0.05或P<0.01）。然而，外周血中CD4+ T细胞水平及CD4+/CD8+比值显著降低。
全蝎蜈蚣治疗大鼠类风湿性关节炎的机制可能是调节外周血及肠道T淋巴细胞亚群的平衡。
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