鼻腔内吸入氟尼缩松治疗非变应性鼻炎。

Intranasal flunisolide treatment in patients with non-allergic rhinitis.

机构信息

U.O.C. O.R.L.-Ospedale San Gennaro, ASL Na1, Naples, Italy.

出版信息

Int J Immunopathol Pharmacol. 2011 Apr-Jun;24(2):401-9. doi: 10.1177/039463201102400213.

DOI:10.1177/039463201102400213

Abstract

Non-allergic rhinitis (NAR) is a heterogeneous disease, characterized by nasal hyperreactivity and inflammation. Its treatment is still debated, intranasal corticosteroids may be an option. The present study is aimed at evaluating the effect of the use of intranasal flunisolide in patients with NAR, considering both clinical and cytological parameters. Sixty patients were treated with intranasal flunisolide (30) or saline solution (30) for 8 weeks. Symptom severity, turbinate size, and inflammatory cell counts were assessed, before and after treatment. Intranasal flunisolide induced a significant reduction of symptoms, turbinate size, and cellular infiltrate. Thus, intranasal flunisolide might be a therapeutic option for NAR.

摘要

非变应性鼻炎（NAR）是一种异质性疾病，其特征为鼻高反应性和炎症。其治疗仍存在争议，鼻内皮质类固醇可能是一种选择。本研究旨在评估鼻内氟尼缩松在 NAR 患者中的使用效果，同时考虑临床和细胞学参数。60 例患者接受鼻内氟尼缩松（30 例）或生理盐水（30 例）治疗 8 周。在治疗前后评估症状严重程度、鼻甲大小和炎症细胞计数。鼻内氟尼缩松可显著减轻症状、鼻甲大小和细胞浸润。因此，鼻内氟尼缩松可能是 NAR 的一种治疗选择。