胶质细胞通过 TGF-β 信号指导发育中的神经元重塑。
Glia instruct developmental neuronal remodeling through TGF-β signaling.
机构信息
Department of Neurobiology, University of Massachusetts, Worcester, Massachusetts, USA.
出版信息
Nat Neurosci. 2011 Jun 19;14(7):821-3. doi: 10.1038/nn.2833.
Abstract
We found that glia secrete myoglianin, a TGF-β ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.
摘要
我们发现神经胶质细胞分泌肌球蛋白，一种 TGF-β 配体，以指示果蝇发育中的神经重塑。神经胶质细胞的肌球蛋白上调了蜕皮激素核受体在幼虫后期蜕皮激素高峰后的神经元表达，从而触发神经突重塑。因此，神经胶质细胞不仅通过吞噬不需要的神经突，而且通过使神经元重塑来协调发育中的神经重塑。
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