血液透析患者万古霉素的体重剂量调整。
Weight-based loading of vancomycin in patients on hemodialysis.
机构信息
Department of Pharmacy, Hahnemann University Hospital, Philadelphia, Pennsylvania, USA.
出版信息
Clin Infect Dis. 2011 Jul 15;53(2):164-6. doi: 10.1093/cid/cir322.
PMID:21690623
Abstract
We evaluated weight-based loading doses of vancomycin and resulting initial prehemodialysis concentrations. Modeling demonstrated modest correlation between dose administered, age, and initial concentration achieved. Actual body weight-based loading of vancomycin predictably achieves therapeutic initial concentrations in patients who receive hemodialysis.
摘要
我们评估了万古霉素基于体重的负荷剂量和由此产生的初始透析前浓度。模型表明，给予的剂量、年龄和初始浓度之间存在适度的相关性。对于接受血液透析的患者，基于实际体重的万古霉素负荷剂量可预测性地达到治疗性初始浓度。
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